MacPorts for as much as I could. I also avoided using the prebuilt binaries. I got PCL 1.4 from the trunk and built it myself.
I followed the Mac install tutorial to get all of the dependencies, used xcode 4.2.1 to compile and run the pclvisualizer tutorial. I had to do a couple of extra steps after this, but once you've gotten through the Mac install tutorial then post back here and we'll go from there.
Ah I've managed to get it working with cmake (using PCL 1.3 and the homebrew formulae).
To compile using Xcode is a fun task however.. did you need to create any alias links? Can't just copy the dynamic libraries in as their header files report missing links (e.g. pcl/io/file_io.h not found).